DM : clinical picture and metabolic disterbunce

Hi all, here we meet again in our short medical articles. In addition, I will continue our health topic on DM, as I will talk about DM clinical picture in next few lines of my cool medical article.
DM clinical picture divided to four different presentations:
1. Acute presentation, which characterized but not limited to:
·       Polyuria due to osmotic diuresis
clinical picture

·       Polydipsia due to loss of fluid
·       Polyphagia as decreased insulin leads to inability of glucose to enter satiety center.
·       Weakness or fatigue
·       Pruritis or vulvovaginits
·       Weight loss as a result of fluid depletion and breakdown of fat and proteins
·       Mood changes, irritability, difficulty of concentration and apathy.
·       Here the last presentation may be horrible health event causing a health problem called ketoacidosis.
Not all the above symptoms may be recognized except ketoacidosis, now to the next presentation.
2. Sub-acute presentation:
  • ·       Blurring of vision due to glucose induced changes of refraction.
  • ·       Pruritis vulvae (candida infection), in addition to polyuria and weight loss

Lots of information about health, keep on here is the third presentation.
3. Complication as a presenting feature: (complication will be discussed in a separate short medical article)
  • ·       Staph skin infection
  • ·       Nephropathy
  • ·       Retinopathy
  • ·       Impotence
  • ·       Coronary heart diseases
  • ·       UTI
  • ·       Neuropathy
We all know that presentation with those complications means uncontrolled long standing DM
It is time for fourth and last presentation.
4. Asymptomatic diabetes:
Glycosuria or hyperglycemia discovered during routine investigations.
Before saying good bye as usual, I will give a brief hint on metabolic disturbance in DM.
As diabetes mellitus is a deficiency or resistance of insulin so that leads to hyperglycemia which in turn may exceed renal threshold for glucose (180 mg%) that leads to glycosuria.
Added to that due to defective glucose utilization, fatty acids are released from adipose tissue and deposited in liver leading to fatty liver.
Part of those fatty acids transformed into acetoacetic acid and beta hydroxyl butyric acid (ketone bodies) which become source of energy but if accumulate in blood, it will lead to ketosis then ketoacidosis followed by coma. (revise fatty acid metabolism in this article:http://www.healthadvicepro.com/2017/02/fats-and-proteins-nutrition.html )
In severe cases of DM, protein synthesis become inhibited and aminoacids are converted into glucose leading to –ve nitrogen balance and muscle wasting.
Wow, I got a headache from all that but seriously this short medical article is full of latest information about health.  So keep tuned up for more amazing medical articles.
Good bye


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